Vasculitis & polymyalgia rheumatica
Predictors for pulmonary artery involvement in Takayasu arteritis and its cluster analysis
Authors' conclusion
In TAK, PAI is associated with thoracic aorta involvement. In TAK patients with PAI, the involvement of the upper lobe of the right lung is characterized with the worst prognosis.
Study context
- Population
- Patients with TAK
- Participants
- 141 patients
- Exposure
- TAK with PAI vs TAK without PAI
- PAIn = 65
- Outcome
- All-cause mortality
Methodological detailsmultivariate logistic regression, cluster analysis
- Multivariate logistic regression
- Cluster analysis
Main finding
As reported in the abstract
Cumulative incidence of events
- TAK with PAI had a significantly higher cumulative incidence of events than those without PAI
- PAI vs Without PAI: P < 0.001
Observational data: associations, not effects.
Further findings
Disease duration
P = 0.012
Hemoptysis
P = 0.040
Oppression in the chest
P = 0.014
Fever
P = 0.024
Mycobacterium tuberculosis infection
P = 0.010
Pulmonary hypertension
P < 0.001
Pulmonary infarction
P < 0.001
Hypoxemia
P < 0.001
Factors associated with PAI (multivariate logistic regression, TAK with symptom presentation)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Oppression in the chest | 2.304 (1.024–5.183) | P = 0.044 | |
| Thoracic aorta involvement | 2.819 (1.165–6.833) | P = 0.022 | |
| 0.10.31310Odds ratio (log scale) |
- Prevalence of PAI
- 46.1% · 65
Prognosis by cluster (TAK with PAI)
- Cluster characterized as the upper lobe of the right lung (Cluster1) had the worst prognosis
Original publication
Predictors for pulmonary artery involvement in Takayasu arteritis and its cluster analysis. Arthritis Res Ther. Published 14 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →