Vasculitis & polymyalgia rheumatica
Proteomics Landscape Mapping of Organ‐Resolved Behçet's Disease Using In‐Depth Plasma Proteomics for Identifying Hyaluronic Binding Protein 2 Expression Associated With Vascular Involvement
Authors' conclusion
Our results provide valuable insight into the pathogenesis of organ-resolved BD in terms of proteomics characteristics and potential biomarkers for clinical assessment and potential therapies for vascular BD.
Study context
- Population
- Patients with Behçet's disease (BD) involving different organs and healthy controls; validation cohort of 108 BD patients and 29 healthy controlsvalidation: 108 BD, 29 controls
- Participants
- 98 vs 31
- Comparison
- BD vs healthy controls
- BDn = 98
- Healthy controlsn = 31reference
- Outcome
- Differentially expressed plasma proteins, BD vs healthy controls
Methodological detailsin-depth plasma proteomics (data-independent acquisition mass spectrometry and antibody microarray), independent validation cohort (ELISA)
- In-depth plasma proteomics (data-independent acquisition mass spectrometry and antibody microarray)
- Independent validation cohort (ELISA)
Main finding
As reported in the abstract
- Differentially expressed proteins in BD
- 220
Observational data: associations, not effects.
Original publication
Proteomics Landscape Mapping of Organ‐Resolved Behçet's Disease Using In‐Depth Plasma Proteomics for Identifying Hyaluronic Binding Protein 2 Expression Associated With Vascular Involvement. Arthritis Rheumatol. Published 12 January 2023. doi:10.
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