Vasculitis & polymyalgia rheumatica
High prevalent early damage independently predicts future mortality in an inception cohort of Takayasu arteritis
Authors' conclusion
Most patients with TAK had recordable early damage, which was associated with future mortality.
Study context
- Population
- Inception cohort of patients with TAK, damage scored with the Large Vessel Vasculitis Index of Damage (LVVID)141 females
- Participants
- 199 participants
- Outcome
- Early damage (LVVID), its evolution and prognostic relevance (mortality)
- Follow-up
- Within 3 months of cohort entry, 1 year and last
Methodological detailsCox proportional hazards regression, paired Student's t test, logistic regression
- Cox proportional hazards regression
- Paired Student's t test
- Logistic regression
Main finding
As reported in the abstract
- Damage at presentation
- 192/199 (96.5%)
- Damage at 1 year
- 112/114 (98.2%)
- Damage at last follow-up
- 126/130 (96.9%)
- Mortality, crude HR per point increase in baseline LVVID
- 1.49 (95% CI 1.24-1.81)
- Mortality, HR per quartile increase in LVVID
- 1.92 (95% CI 1.21-3.05)
Observational data: associations, not effects.
Further findings
Initial LVVID by characteristics
- Initial LVVID greater with active disease, Hata's type V, or Goel's cluster 1 angiographic subtypes
LVVID progression
- 1 year vs baseline (P < 0.001)
- 3.49 ± 2.01 vs 3.27 ± 1.86
- Last follow-up vs baseline (P < 0.001)
- 3.73 ± 2.18 vs 3.28 ± 1.88
Predictors of LVVID progression
- Active disease at presentation, OR
- 2.89
- GC use, OR
- 3.53
- Immunosuppressant use, OR
- 3.52
Original publication
High prevalent early damage independently predicts future mortality in an inception cohort of Takayasu arteritis. Rheumatology (Oxford). Published 25 September 2025. doi:10.
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