Vasculitis & polymyalgia rheumatica
Prevalence and prognostic relevance of electrocardiographic abnormalities among patients with ANCA-associated vasculitis
Main finding · Cardiovascular mortality, AAV with major ECG abnormalities vs controlsResult — go to the resultHazard ratio 1.99 CI 1.49–2.65Authors' conclusion
Patients with AAV demonstrated a higher prevalence of major ECG abnormalities than controls. Notably, major ECG abnormalities were associated with a significantly increased risk of cardiovascular mortality.
Study context
- Population
- Patients with GPA or MPA with digital ECGs, Danish registers 2000–2021 (median age 69 years, 52.3% male)1,431 ANCA-associated vasculitis (AAV) patients
- Exposure
- AAV patients vs matched controls without AAV, by ECG abnormalities
- AAVn = 1,431
- Outcome
- Cardiovascular mortality according to ECG abnormalities (no, minor or major)
- Follow-up
- 5 years
Methodological detailsrisk-set matched (1:3) on age, sex and year of ECG measurement, Danish registers, Cox regression adjusted for age, sex and comorbidities, Median follow-up 4.8 years
- Risk-set matched (1:3) on age, sex and year of ECG measurement
- Danish registers
- Cox regression adjusted for age, sex and comorbidities
- Median follow-up 4.8 years
Main finding
As reported in the abstract
Cardiovascular mortality, AAV with major ECG abnormalities vs controls
Hazard ratio
1.99
CI 1.49–2.65
AAVvs Controls
HR 1.99 (CI 1.49–2.65)
Observational data: associations, not effects.
Further findings
Prevalence of left ventricular hypertrophy
Prevalence of ST-T deviations
Prevalence of AF
Prevalence of QTc prolongation
| Outcome | AAV | Controls |
|---|---|---|
| 5-year risk of cardiovascular mortality (standardized), major ECG abnormalities | 19.14% (CI 16–22%) | 9.41% (CI 8–11%) |
Original publication
Prevalence and prognostic relevance of electrocardiographic abnormalities among patients with ANCA-associated vasculitis. Rheumatology (Oxford). Published 12 August 2024. doi:10.
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