Vasculitis & polymyalgia rheumatica
Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis
Authors' conclusion
Exposure to environmental PM10 in the preceding 60 days seems to be associated with an increased risk of developing GCA, especially in older individuals with prolonged exposure to high levels of air pollution.
Study context
- Population
- Consecutive patients diagnosed with giant cell arteritis (GCA) in three hospitals in northern Italy, 2013–2021
- Participants
- 232 patients
- Comparison
- PM10 exposure and GCA onset or ischemic complications
- Outcome
- GCA symptoms onset associated with PM10 exposure
- Follow-up
- 60-day period
Methodological detailsconsecutive patients, three hospitals, Bayesian hierarchical exposure model, conditional logistic regression
- Consecutive patients
- Three hospitals
- Bayesian hierarchical exposure model
- Conditional logistic regression
Main finding
As reported in the abstract
GCA risk per 10-μg/m³ increase in PM10 within 60 days
Incremental odd of GCA per 10-μg/m³ increase in PM10
27.1%
95% CI 5.8–52.6
Further findings
GCA onset vs PM10 in preceding 60 days by chronic exposure (subgroup)
GCA risk for shorter periods and ischemic complications
- No significant association for shorter periods or with ischemic complications
GCA risk in patients ≥70 years old (subgroup) · 60-day lag
- Significantly higher incremental risk for patients ≥70 years old
GCA onset vs PM10 in preceding 60 days by chronic exposure (subgroup)
- Association between GCA onset and increased PM10 only in chronically high-exposed
Original publication
Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis. Arthritis Care Res (Hoboken). Published 9 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →