Vasculitis & polymyalgia rheumatica
Epidemiology of eosinophilic granulomatosis with polyangiitis in Northern Italy: a population-based capture-recapture study
Authors' conclusion
EGPA prevalence in Northern Italy is among the highest reported in Europe, likely reflecting near-complete case ascertainment through integrated health data sources rather than true geographic variation.
Study context
- Population
- Patients with eosinophilic granulomatosis with polyangiitis (EGPA) in the Reggio Emilia area, Northern Italy, 1991–2022 (mean age 55 years, 75% female)36 prevalent cases
- Participants
- 40 patients
- Outcome
- Prevalence and incidence of EGPA
Methodological detailsmulti-source capture-recapture, seven independent sources, 2022 ACR/EULAR classification criteria
- Multi-source capture-recapture
- Seven independent sources
- 2022 ACR/EULAR classification criteria
Main finding
As reported in the abstract
Crude prevalence per million inhabitants (95% CI 68-72), January 1, 2023
68
Missed prevalent cases estimated by best-fitting capture-recapture model
0
95% CI 0 to 2
Age- and sex-standardized incidence per million inhabitants, 2001–2022
3.31
95% CI 2.24–4.37
Incident cases identified, 2001–2022
37
Observational data: associations, not effects.
Further findings
Standardized incidence by period, per million inhabitants
- 2001-2011
- 2.83 (95% CI 1.39-4.27)
- 2012-2022
- 3.59 (95% CI 2.08-5.09)
- 0 missed cases in both periods (95% CI 0-3 and 0-2, respectively)
Source capture of prevalent cases
- Hospital discharge data
- 25%
- Exemption registry
- 86%
Original publication
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