Vasculitis & polymyalgia rheumatica
Epidemiology and clinical characteristics of polyarteritis nodosa in Japan: findings from a nationwide survey
Authors' conclusion
This epidemiological study revealed the number and sex ratio of patients with PAN in Japan, along with their clinical characteristics. It also detailed the features of cutaneous arteritis.
Study context
- Population
- Patients with PAN treated at hospitals in Japan identified in the first nationwide epidemiological survey868 reported in first survey
- Participants
- 547 patients
- Outcome
- Epidemiological and clinical characteristics of PAN
Methodological detailsnationwide survey, secondary questionnaire, randomly selected facilities
- Nationwide survey
- Secondary questionnaire
- Randomly selected facilities
Main finding
As reported in the abstract
- Male
- 233
- Female
- 314
- Male-to-female ratio
- 1:1.3
- Mean age at diagnosis, years (± SD)
- 51.7 ± 17.6
- Fever
- 43.4%
- Skin involvement
- 82.4%
- Joint/muscle involvement
- 51.6%
- Oral GC prescribed
- 95.4%
- Concomitant immunosuppressants
- 78.6%
- AZA
- 59.3%
- CYC
- 49.3%
- Remission
- 91.2%
- Relapse
- 47.8%
Observational data: associations, not effects.
Further findings
Risk factors for relapse
- Skin involvement was a risk factor for relapse
- Fever was associated with a lower risk of relapse
Cutaneous arteritis (met diagnostic criteria)
- Proportion of the 547 patients
- 14.4%
- Male-to-female ratio
- 1:3.9
- Mean age at onset, years (± SD)
- 47.5 ± 14.5
Pediatric-onset PAN (onset at age 18 years or younger)
- Patients
- 22
- Male ratio (higher)
- 1.8:1
- Higher frequency of fever and skin involvement
Original publication
Epidemiology and clinical characteristics of polyarteritis nodosa in Japan: findings from a nationwide survey. Semin Arthritis Rheum. Published 29 July 2026. doi:10.
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