Vasculitis & polymyalgia rheumatica
Behçet’s syndrome epidemiology in England: a real-world retrospective cohort analysis with a nested case-control study using linked UK primary and secondary care data
Authors' conclusion
BS prevalence appears to increase over time in the UK, potentially linked to changing population demographics and migration, and to performance characteristics of the 2014 International Criteria for Behçet's Disease classification criteria in low-prevalence settings.
Study context
- Population
- Patients with Behçet's syndrome in England, Clinical Practice Research Datalink (CPRD) Aurum and linked Hospital Episode Statistics (HES), 2001–20211,565 incident behçet's syndrome (BS) cases
- Participants
- 1,628 vs 11,190
- Comparison
- BS cases vs matched controls; incidence and prevalence of BS
- BSn = 1,628
- Controlsn = 11,190reference
- Outcome
- Incidence and prevalence of BS
Methodological detailslinked primary and secondary care data (CPRD Aurum and HES), matched case-control design, Case ascertainment relied on diagnostic coding without direct validation against classification criteria
- Linked primary and secondary care data (CPRD Aurum and HES)
- Matched case-control design
- Case ascertainment relied on diagnostic coding without direct validation against classification criteria
Main finding
As reported in the abstract
Incident BS cases in study interval
1565
Incidence rate in 2021 (per 100 000 person years at risk)
0.75/100 000
Prevalence rose from (per 100 000 person years)
8.62
Prevalence rose to (per 100 000 person years)
19.80
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Clinical triad (genital ulceration, uveitis, oral ulceration), nested case-controlBS vs Controls · genital ulceration · matched case-control | aOR 155.08 |
| Clinical triad (genital ulceration, uveitis, oral ulceration), nested case-controlBS vs Controls · uveitis · matched case-control | aOR 43.00 |
| Clinical triad (genital ulceration, uveitis, oral ulceration), nested case-controlBS vs Controls · oral ulceration · matched case-control | aOR 24.73 |
| Crohn's disease, nested case-controlMatched case-control | OR 5.69 |
BS prevalence over the study interval · 2001–2021
- Prevalence rose from (per 100 000 person years)
- 8.62
- Prevalence rose to (per 100 000 person years)
- 19.80
Time from first clinical code of genital ulceration to BS diagnosis (shortest interval of manifestations)
- Median interval to diagnosis after first genital ulceration code
- 240 days; IQR 63-745
Original publication
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