Vasculitis & polymyalgia rheumatica
Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study
Authors' conclusion
Age ≥65 years and serum creatinine >140 μmol/L at diagnosis, as well as gastrointestinal and CNS involvement, are independent predictors of death in sPAN.
Study context
- Population
- Patients with polyarteritis nodosa (PAN) recruited 1990–2020 from observational cohorts of nine countries across Europe, Japan and North America; eligibility by EMA classification algorithm; HBV-related PAN, DADA2 and FMF excluded25 pediatric onset
- Participants
- 358 patients
- Exposure
- Systemic PAN (sPAN) vs Cutaneous PAN
- sPANn = 282
- Cutaneous PANn = 76
- Outcome
- Clinical features, relapse and survival
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
- Age at diagnosis, mean ± SD (years)
- 44.3 ± 18.1
- Constitutional symptoms
- 71.5%
- Cutaneous involvement
- 70.5%
- Musculoskeletal findings
- 69.1%
- Neurologic features
- 48.0%
- Relapse during median (IQR) 59.6 (99.5) months of follow-up
- 48.5%
Observational data: associations, not effects.
Further findings
Organ involvement in sPAN
- Gastrointestinal involvement
- 52.2%
- Proteinuria over 400 mg/day
- 11.2%
Survival in sPAN · 1, 5 and 10 years
- 1-year survival
- 97.1%
- 5-year survival
- 94.0%
- 10-year survival
- 89.0%
Predictors of death in sPAN
- Age ≥65 years at diagnosis, serum creatinine at diagnosis >140 μmol/L, gastrointestinal manifestations and central nervous system (CNS) involvement predicted death
Original publication
Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study. Arthritis Rheumatol. Published 22 February 2024. doi:10.
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