Prevalence of anti-neutrophil cytoplasmic antibody-associated vasculitis in the south of France, using the capture-recapture method

Rubenstein, E; Henneton, P; Rivière, S; Casanova, ML; Broner, J; Arnaud, E; Oziol, E; Le Quintrec, M; Moranne, O; Jorgensen, C; Combe, B; Bourdin, A; Fontaine, C; Schiffmann, A; Fraison, JB; Hallé, O; Fraisse, T; Veysseyre, F; Taieb, G; Aerts, C; Crampette, L; Alovisetti, C; Guis, L; Mehlal, S; Papinaud, L; Le Quellec, A; Guilpain, P; Mahr, A

doi:10.1093/rheumatology/kead557

Vasculitis & polymyalgia rheumatica

Prevalence of anti-neutrophil cytoplasmic antibody-associated vasculitis in the south of France, using the capture-recapture method

Rheumatology (Oxford)Published 11 Oct 2023Cross-sectional study

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Authors' conclusion

We provide a new estimate of AAV prevalence in France and show a higher prevalence of MPA in non-European patients.

Study context

Population: Adults ≥15 years diagnosed with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) or eosinophilic granulomatosis with polyangiitis (EGPA), living in Hérault and Gard (Southern France) in 2018; cases defined by ACR/EULAR classification criteria and, if necessary, the European Medicines Agency algorithm
Participants: 202 adults

Exposure: GPA vs MPA vs EGPA
GPAn = 86
MPAn = 85
EGPAn = 31
Outcome: Standardised prevalence of AAV per million inhabitants
Follow-up: 2018

Methodological detailspopulation-based, capture-recapture analysis, four sources, standardised to the world population, Four sources: hospitals, community-based physicians, laboratories, National Health Insurance

Population-based
Capture-recapture analysis
Four sources
Standardised to the world population
Four sources: hospitals, community-based physicians, laboratories, National Health Insurance

Main finding

As reported in the abstract

Standardised prevalence per million inhabitants

AAV10395% CI 84–125 · per million inhabitants

GPA4895% CI 35–64 · per million inhabitants

MPA3995% CI 28–53 · per million inhabitants

EGPA1695% CI 9–26 · per million inhabitants

Observational data: associations, not effects.

Further findings

Standardised prevalence by ANCA status, per million inhabitants · 2018

Anti-PR3 positive AAV36 per million inhabitants95% CI 25–50

Anti-MPO positive AAV46 per million inhabitants95% CI 34–61

ANCA-negative AAV16 per million inhabitants95% CI 9–26

ANCA-associated vasculitis (AAV) cases by geographical origin · Non-European residents vs European residents · number of AAV cases higher for non-European residents: P = 0.001
AAV cases by geographical origin · Non-European residents vs European residents · MPA: higher for non-European residents: P < 0.0001

Comprehensiveness of the estimation (capture-recapture)

Global estimation of comprehensiveness: 80.5%

Original publication

Prevalence of anti-neutrophil cytoplasmic antibody-associated vasculitis in the south of France, using the capture-recapture method. Rheumatology (Oxford). Published 11 October 2023. doi:10.1093/rheumatology/kead557

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