Vasculitis & polymyalgia rheumatica
Epidemiology of anti-neutrophil cytoplasmic antibodies (ANCA) vasculitis in northern Spain
Authors' conclusion
During a 20-year period we found that the incidence of AAV (GPA and MPA) in northern Spain was higher than in southern Spain, but lower than northern European countries. An increase in the incidence was observed in the last years.
Study context
- Population
- AAV patients diagnosed Jan 2000–Dec 2023 in Cantabria, northern Spain; EGPA excluded80M/72F
- Participants
- 152 patients
- Exposure
- Microscopic polyangiitis (MPA) vs granulomatosis with polyangiitis (GPA) vs Unclassified vasculitis
- MPAn = 67
- GPAn = 64
- Unclassified vasculitisn = 21
- Outcome
- Annual incidence of AAV (cases per 10^6)
Methodological detailsACR/EULAR 2022 classification criteria, literature review
- ACR/EULAR 2022 classification criteria
- Literature review
Main finding
As reported in the abstract
Annual incidence of AAV, per 10^6
- Overall annual incidence (95% CI 10, 16.8) /10^6
- 13.4
- Male
- 14.5 (95% CI 10.5, 18.5)
- Female
- 12.1 (95% CI 8.7, 15.6)
- MPA (95% CI 4, 7.8) /10^6
- 5.9
- GPA (95% CI 3.9, 7.3) /10^6
- 5.6
Observational data: associations, not effects.
Further findings
Trend in mean annual incidence of AAV, per 10^6 · last 3 years
- Earlier mean annual incidence
- 6.1 (95% CI 4.5, 7.7)
- Last 3 years
- 16.5 (595% CI: .6, 27.4, as printed)
- GPA earlier
- 2.3 (95% CI 0.3, 4.9)
- GPA last 3 years
- 8.2 (95% CI 2, 14.5)
Prevalence of AAV, per 10^6
- Prevalence
- 184.7 (95% CI 181, 188)
Original publication
Epidemiology of ANCA vasculitis in northern Spain. Rheumatology (Oxford). Published 6 August 2024. doi:10.
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