Vasculitis & polymyalgia rheumatica
Clinicopathological characteristics of severe aortic valve regurgitation caused by Behçet's syndrome
Authors' conclusion
Overall, our study provides valuable insights into the pathology of severe AR caused by BS as a mixed inflammatory infiltration and provides the first pathological rationale for achieving preoperative remission and early biologics to improve the prognosis.
Study context
- Population
- Behçet's syndrome (BS) patients with severe AR who underwent cardiac surgery with retained pathological specimens (mean diagnosis age 39.6±13.1 years)
- Participants
- 22 patients
- Exposure
- Active vs remission phase at surgery; preoperative biologics vs no biologics
- Activen = 7
- Remissionn = 15reference
- Outcome
- Pathology of severe AR caused by BS
Methodological detailsimmunohistochemistry, re-analysis of retained surgical specimens
- Immunohistochemistry
- Re-analysis of retained surgical specimens
Main finding
As reported in the abstract
- Mixed inflammatory cell infiltration in the aortic wall
Observational data: associations, not effects.
Further findings
| Outcome | Active | Remission | Preoperative biologics | No preoperative biologics | P value |
|---|---|---|---|---|---|
| Diffuse CD4+ T cell infiltration, aortic adventitiaActive vs Remission | 100% | 8.3% | — not stated in the abstract | — not stated in the abstract | P = 0.0002 |
| Diffuse CD8+ T cell infiltration, aortic adventitiaActive vs Remission | 71.4% | 20% | — not stated in the abstract | — not stated in the abstract | P = 0.058 |
| Neutrophil infiltration, aortic valveActive vs Remission | 60% | 7.7% | — not stated in the abstract | — not stated in the abstract | P = 0.044 |
| CD68+ macrophage infiltration, aortic adventitiaPreoperative biologics vs No preoperative biologics | — not stated in the abstract | — not stated in the abstract | 0% | 57.2% | P = 0.045 |
| CD4+ T cell diffusion, aortic adventitiaPreoperative biologics vs No preoperative biologics | — not stated in the abstract | — not stated in the abstract | 0% | 57.1% | P = 0.045 |
| Vasa vasorum mucoid degeneration, aortic adventitiaPreoperative biologics vs No preoperative biologics | — not stated in the abstract | — not stated in the abstract | 20% | 85.7% | P = 0.017 |
| Aortic valve necrosisPreoperative biologics vs No preoperative biologics | — not stated in the abstract | — not stated in the abstract | 0% | 71.4% | P = 0.023 |
— not stated in the abstract
Original publication
Clinicopathological characteristics of severe aortic valve regurgitation caused by Behçet's syndrome. Clin Exp Rheumatol. Published 11 August 2024. doi:10.
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