Vasculitis & polymyalgia rheumatica
Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis
Authors' conclusion
To our knowledge, this study is the first to show association between FXI and a prothrombotic state in EGPA.
Study context
- Population
- Consecutive eosinophilic granulomatosis with polyangiitis (EGPA) patients in remission
- Participants
- 34 patients
- Exposure
- Increased FXI vs FXI ≤130%
- FXI>130%n = 8
- Outcome
- Increased FXI level (>130%) and associated inflammatory and fibrin clot features
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
FXI>130%
23.5%
8
- Eosinophil count, FXI>130% vs FXI ≤130%
- +365%
- Percentage of neutrophils, FXI>130% vs FXI ≤130%
- −20.4%
- Clot permeability (Ks), FXI>130% vs FXI ≤130%
- −20.5%
- Fibrin fiber thickness, FXI>130% vs FXI ≤130%
- −17.5%
Observational data: associations, not effects.
Further findings
Associations of FXI and FXII
- No correlations between FXI and FXII levels or between FXII and eosinophil count
- all p>0.05
- FXI not associated with CRP, fibrinogen or ANCA titers
Original publication
Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis. Clin Exp Rheumatol. Published 21 July 2023. doi:10.
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