Vasculitis & polymyalgia rheumatica
Overlapping macrophage immune profiles in polymyalgia rheumatica and giant cell arteritis
Authors' conclusion
The macrophage immune profiles are remarkably similar in PMR SABBs and GCA TABs.
Study context
- Population
- Patients with active polymyalgia rheumatica (PMR) (subacromial bursa biopsies) and patients with giant cell arteritis (GCA) (temporal artery biopsies)
- Participants
- 11 vs 14
- Comparison
- PMR-affected subacromial bursa biopsies (SABBs) vs GCA-affected temporal artery biopsies (TABs)
- PMRn = 11
- GCAn = 14
- Outcome
- Percentage of cells positive for macrophage markers (CD68, CD64, CD86, CD206, FRβ) and macrophage-related cytokines (GM-CSF, IL-6, IL-23, IFN-γ, M-CSF, TNF-α)
Methodological detailsimmunohistochemical staining, quantitative scoring of positively stained cells
- Immunohistochemical staining
- Quantitative scoring of positively stained cells
Main finding
As reported in the abstract
Macrophage-related immune profiles in PMR SABBs vs GCA TABs
- All macrophage-related markers and cytokines expressed in both PMR SABBs and GCA TABs
- Proportions of cells expressing CD68, CD64, CD86, CD206 and GM-CSF, IL-6, IL-23, IFN-γ, M-CSF, TNF-α comparable between the two tissue types
- FRβ expression relatively higher in GCA TABs than in PMR SABBs
Original publication
Overlapping macrophage immune profiles in polymyalgia rheumatica and giant cell arteritis. Rheumatology (Oxford). Published 27 November 2025. doi:10.
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