Vasculitis & polymyalgia rheumatica
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways
Authors' conclusion
Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.
Study context
- Population
- Temporal artery biopsies (TABs) of giant cell arteritis (GCA), polymyalgia rheumatica (PMR) and non-GCA/non-PMR patients; synovial tissue from inflammatory arthritis and aorta tissue as disease controls
- Participants
- 75 / 22 / 10
- Comparison
- GCA vs PMR temporal artery biopsies
- GCAn = 75
- PMRn = 22reference
- Non-GCA/non-PMRn = 10
- Outcome
- Proportion of senescent cells in temporal arteries
Methodological detailsretrospective, senescence specific multimarker algorithm, triple costaining, artery culture supernatant experiments
- Retrospective
- Senescence specific multimarker algorithm
- Triple costaining
- Artery culture supernatant experiments
Main finding
As reported in the abstract
Senescent cells in arteries
P < 0.0001
Further findings
IL-6(+) senescent cells by extension of vascular inflammation
P < 0.0001
Original publication
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways. Ann Rheum Dis. Published 15 February 2024. doi:10.
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