Vasculitis & polymyalgia rheumatica
Maternal and fetal outcomes of pregnancy in women with primary systemic vasculitis: A single-center cohort study of 20 patients and 30 pregnancies
Authors' conclusion
This cohort study shows that vasculitis relapses during pregnancy and post-partum, together with other pregnancy complications, occur in a considerable number of patients with systemic vasculitides, although a final good pregnancy outcome can be expected in most cases.
Study context
- Population
- Pregnant women with primary systemic vasculitis followed 2009–2022 at the High-Risk Pregnancy Clinic, Hospital Clínic, Barcelona
- Participants
- 20 women30 pregnancies
- Outcome
- Maternal and fetal pregnancy outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Pregnancy outcomes (30 pregnancies)
- Vasculitis flare during pregnancy
- 4 (13.3 %)
- Post-partum relapses among successful pregnancies
- 4 (16.7 %)
- Pregnancies resulting in live babies
- 80%
- Medical termination of pregnancy
- 4 (13.3 %)
- Spontaneous miscarriages
- 2
- Stillbirths or neonatal deaths
- 0
- Preeclampsia (most frequent maternal complication)
- 25 %
- Preterm newborns
- 24 %
- Low birthweight newborns
- 20 %
Observational data: associations, not effects.
Further findings
Disease status before pregnancy
- Median time from diagnosis to pregnancy, years (range 2 months-29 years)
- 5.8
- In remission at conception
- 76.7 %
- AAV
- 7
- BD
- 4
Maternal deaths
- No maternal deaths occurred
Original publication
Maternal and fetal outcomes of pregnancy in women with primary systemic vasculitis: A single-center cohort study of 20 patients and 30 pregnancies. Semin Arthritis Rheum. Published 14 February 2024. doi:10.
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