Vasculitis & polymyalgia rheumatica
Pregnancy outcomes in patients with systemic vasculitis in the USA from 2007 to 2022: an administrative claims-based study
Authors' conclusion
Pregnancies in patients with vasculitis had higher risks of preterm delivery and pre-eclampsia or eclampsia than pregnancies in the referent obstetric population.
Study context
- Population
- Pregnancies in patients aged 15–44 years at delivery, Merative MarketScan Commercial Databases (mostly privately insured), USA, Jan 1, 2007, to Dec 31, 2022pregnancies
- Participants
- 568 vs 5,680
- Exposure
- Pregnancies in patients with systemic vasculitis vs pregnancies in obstetric patients without vasculitis
- Vasculitisn = 568
- Referent populationn = 5,680reference
- Outcome
- Adverse pregnancy outcomes, including hypertensive disorders of pregnancy, placental disorders and preterm delivery phenotypes
Methodological detailsadministrative claims-based, minimally adjusted and propensity score-adjusted regression models
- Administrative claims-based
- Minimally adjusted and propensity score-adjusted regression models
Main finding
As reported in the abstract
Preterm delivery (before 37 weeks completed gestation)
Each group vs referent populationEstimate (95% CI)
Vasculitis
adjusted RR (minimally adjusted model) 1.76(1.33–2.33)
Vasculitis
propensity score-adjusted RR 1.52(1.13–2.03)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Pre-eclampsia or eclampsia | minimally adjusted RR 1.91 (95% CI 1.45–2.52) | |
| Pre-eclampsia or eclampsia | propensity score-adjusted RR 1.51 (95% CI 1.11–2.07) | |
| 0.20.5125Ratio (log scale) |
Age at delivery
Pre-eclampsia or eclampsia
- Risk varied by parity and vessel size
Vasculitis pregnancies by vessel size
- Large vessel vasculitis
- 61 (8.4%)
- Medium vessel vasculitis
- 171 (23.5%)
- Small vessel vasculitis
- 247 (33.9%)
- Variable vessel vasculitis
- 274 (37.6%)
Medication use during pregnancy (vasculitis)
- GC most common treatment; receiving other immunosuppressive medications
- 159 (21.8%)
Original publication
Pregnancy outcomes in patients with systemic vasculitis in the USA from 2007 to 2022: an administrative claims-based study. Lancet Rheumatol. Published 17 October 2025. doi:10.
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