Vasculitis & polymyalgia rheumatica
Role of bronchoscopy for respiratory involvement in eosinophilic granulomatosis with polyangiitis
Authors' conclusion
Bronchoscopy plays a crucial role in patients with EGPA by detecting endobronchial lesions, providing definitive pathological evidence, and identifying eosinophilic infiltration or infections.
Study context
- Population
- Chinese patients with eosinophilic granulomatosis with polyangiitis (EGPA) who underwent bronchoscopy at initial diagnosis, May 2005 to May 202359 males (54.1%)
- Participants
- 109 patients
- Outcome
- Bronchoscopic findings at diagnosis
- Follow-up
- At diagnosis
Methodological detailsdescriptive
- Descriptive
Main finding
As reported in the abstract
- Mucosal oedema and inflammatory changes
- 95 (87.2%)
- Tracheobronchial stenosis
- 12 (11.0%)
- Mucosal nodules and masses
- 10 (9.2%)
- Bleeding
- 1 (0.9%)
- Transbronchial biopsy (TBB) (n=93) with pathological support for EGPA
- 76 (81.7%)
- TBB eosinophilic infiltration
- 72 (77.4%)
- TBB vasculitis
- 23 (24.7%)
- TBB granulomas
- 7 (7.5%)
- Transbronchial needle aspiration of mediastinal lymph nodes: eosinophilic infiltration and granulomas
- 2
- Bronchoalveolar lavage (BAL) (n=89) eosinophilia (>1%)
- 67 (75.3%)
- BAL median percentage of eosinophils
- 9 (1, 33%)
Observational data: associations, not effects.
Further findings
Clinical, laboratory and chest imaging findings
- Asthma
- 104 (95.4%)
- Rhinosinusitis
- 101 (92.7%)
- Peripheral neuropathy
- 70 (64.2%)
- Eosinophilia (>1.0×109/L)
- 87 (79.8%)
- ANCA positivity
- 18 (16.5%)
- Ground-glass opacities
- 61 (56.0%)
- Bronchial wall thickening and bronchiectasis
- 53 (48.5%)
- Consolidation
- 52 (47.7%)
Original publication
Role of bronchoscopy for respiratory involvement in eosinophilic granulomatosis with polyangiitis. Clin Exp Rheumatol. Published 11 October 2025. doi:10.
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