Vasculitis & polymyalgia rheumatica
Diabetes mellitus and cardiac disease as key predictors of rituximab-induced acute thrombocytopenia in ANCA-associated vasculitis
Authors' conclusion
RIAT is a frequent complication of RTX induction in patients with AAV, with diabetes mellitus and cardiac disease being strong risk factors.
Study context
- Population
- Patients with new-onset MPA or GPA receiving rituximab (RTX) induction, nationwide multicentre registry in Japan
- Participants
- 175 patients
- Outcome
- RTX-induced acute thrombocytopenia (RIAT): platelet count reductions within 28 days post-RTX
- Follow-up
- 28 days post-RTX
Methodological detailsnationwide multicentre registry, logistic regression with stepwise selection, prediction model
- Nationwide multicentre registry
- Logistic regression with stepwise selection
- Prediction model
Main finding
As reported in the abstract
RIAT incidence · within 28 days post-RTX
RTX-induced acute thrombocytopenia (RIAT) occurred
35.4%
Observational data: associations, not effects.
Further findings
Predictors of RIAT
- Diabetes mellitus, OR
- 4.96
- Cardiac disease, OR
- 3.57
- Low platelet count, OR per 104/μl decrease
- 1.04
- Increased serum creatinine, OR per 1 mg/dl increase
- 1.44
- Low albumin, OR per 1 g/dl decrease
- 2.33
- High KL-6, OR per 100 U/ml increase
- 1.09
- Identified as significant predictors
Predictive model performance
- C-statistic
- 0.817
Original publication
Diabetes mellitus and cardiac disease as key predictors of rituximab-induced acute thrombocytopenia in ANCA-associated vasculitis. Rheumatology (Oxford). Published 10 October 2025. doi:10.
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