Vasculitis & polymyalgia rheumatica
Pregnancy outcomes in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis patients: A systematic review and meta-analysis
Authors' conclusion
The analysis demonstrated higher occurrence of adverse outcomes in pregnant women suffering from AAV accompanied by an increased risk of disease flare during pregnancy.
Study context
- Population
- Pregnancies in patients with AAV (GPA, EGPA, MPA); PubMed, Scopus, Cochrane Library and Cinahl searched until September 2022
- Participants
- 92 pregnancies6 studies
- Outcome
- Prevalence of pre-term delivery, IUGR neonates and disease flare
Methodological detailsrandom effects model, blinded data extraction and risk-of-bias assessment by three investigators
- Random effects model
- Blinded data extraction and risk-of-bias assessment by three investigators
Pooled result
As reported in the abstract
Pooled prevalence of adverse pregnancy outcomes
- Pre-term delivery: 18% (CI: 0.10-0.30), P=non-significant
- Intrauterine growth restriction (IUGR) neonates: 20% (CI: 0.11-0.33), P=non-significant
- Disease flare: 28% (CI: 0.09-0.59), P<0.01
Original publication
Pregnancy outcomes in ANCA-associated vasculitis patients: A systematic review and meta-analysis. Joint Bone Spine. Published 5 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →