Vasculitis & polymyalgia rheumatica
Active disease, fibromyalgia and exposure to glucocorticoids differentially associate with sleep and circadian parameters in Behçet’s syndrome
Authors' conclusion
Fibromyalgia and active disease shape partially diverging sleep and circadian rhythm disruption patterns in BS patients, with glucocorticoids potentially improving BS patients' sleep regularity by limiting disease activity-related sleep disruption.
Study context
- Population
- Patients with Behçet's syndrome (BS)
- Participants
- 45 patients
- Exposure
- Active vs non-active disease; fibromyalgic vs non-fibromyalgic BS patients; GC exposure
- Outcome
- Sleep and circadian rhythm parameters (7-day accelerometry; Pittsburgh Sleep Quality Index; reduced Morningness-Eveningness Questionnaire)
Methodological details7-day accelerometric monitoring, linear regression models
- 7-day accelerometric monitoring
- Linear regression models
Main finding
As reported in the abstract
- Active and fibromyalgic BS patients: lower reported sleep quality and lower objectively recorded sleep efficiency vs non-active and non-fibromyalgic, respectively
- FM associated with shorter total sleep time and a more stable day-to-day rest-activity pattern
- Active disease associated with reduced sleep regularity
- GC exposure associated with increased sleep regularity
Observational data: associations, not effects.
Original publication
Active disease, fibromyalgia and exposure to glucocorticoids differentially associate with sleep and circadian parameters in Behçet’s syndrome. Rheumatology (Oxford). Published 14 March 2025. doi:10.
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