Vasculitis & polymyalgia rheumatica

Sleep and circadian parameters in Behçet’s syndrome: a comparative analysis using actigraphy and questionnaires

Rheumatology (Oxford)Published Cross-sectional study

Authors' conclusion

Active disease and fibromyalgia are associated with sleep and circadian rhythm disturbances in BS patients.

Study context

Population
BD patients (45) and matched healthy controls (HCs)45 Behçet syndrome (BS) patients · 61 HCs
Exposure
BD patients, with or without active disease and comorbid FM, vs HCs
  • HCsn = 61reference
Outcome
Sleep and circadian parameters (actigraphy; Pittsburgh Sleep Quality Index; reduced Morningness-Eveningness Questionnaire)
Methodological detailsage-, BMI-, sex- and smoking habits-matched, actigraphy and questionnaires, linear regression models
  • Age-, BMI-, sex- and smoking habits-matched
  • Actigraphy and questionnaires
  • Linear regression models

Main finding

As reported in the abstract

Sleep and circadian parameters
  • BS with active disease and/or FM: significantly lower sleep quality, significantly higher sleep fragmentation and a tendence towards less robust circadian rhythms vs other participants
  • BS without active disease or FM did not significantly differ from HCs in sleep and circadian parameters

Observational data: associations, not effects.

Further findings

Actigraphically-determined obstructive sleep apnoea syndrome (OSAS) risk

Higher in all BS patients vs HCs

Original publication

Sleep and circadian parameters in Behçet’s syndrome: a comparative analysis using actigraphy and questionnaires. Rheumatology (Oxford). Published 9 June 2025. doi:10.1093/rheumatology/keaf326

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