Vasculitis & polymyalgia rheumatica
Glycolipid metabolic changes during remission induction in ANCA-associated vasculitis: a retrospective study of the lipid paradox
Authors' conclusion
Patients with AAV show a high burden of baseline dyslipidaemia and dynamic glycolipid metabolic changes during remission induction. The observed increase in lipid concentrations together with decreases in fasting glucose and the TC/HDL-C ratio suggests a lipid-paradox pattern and a close relationship between inflammation and metabolic status. Further prospective studies with standardised treatment exposure and cardiovascular outcome assessment are needed to clarify the clinical significance of these metabolic trajectories.
Study context
- Population
- Patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) during remission inductionpatients with AAV
- Participants
- 973 patients
- Exposure
- Paired baseline vs post-remission induction glycolipid parameters in the longitudinal cohort
- Outcome
- Dyslipidaemia at baseline
- Follow-up
- Baseline
Methodological detailsmultivariable models
- Multivariable models
Main finding
As reported in the abstract
- Dyslipidaemia was highly prevalent at baseline
Observational data: associations, not effects.
Further findings
Factors associated with dyslipidaemia · baseline
- Inflammatory markers, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were associated with dyslipidaemia
Glycolipid parameters during remission induction
- Triglyceride, total cholesterol and LDL-C levels increased
- Fasting glucose and the TC/HDL-C ratio decreased
- Consistent with a lipid-paradox pattern
Comparison of patients with and without longitudinal data
- Additional analyses suggested potential selection bias in the longitudinal cohort
Original publication
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