Vasculitis & polymyalgia rheumatica
Clinical features, anti-neutrophil cytoplasmic antibody (ANCA) status, and human leucocyte antigen (HLA) phenotypes of patients diagnosed with both rheumatoid arthritis and granulomatosis with polyangiitis: a case series of six patients with predominant myeloperoxidase (MPO)-ANCA positivity and HLA-DR4/DQ8/DPB1*04:01 phenotype
Authors' conclusion
In this case series of patients diagnosed with both RA and GPA, a long latency period between the two diagnoses was observed in all cases. All patients were women, the majority had erosive arthritis, and many patients were affected by saddle nose deformity and/or subglottic stenosis. MPO-ANCA was present in the majority of patients, which has not been described before. All patients were HLA-DR4/DQ8/DPB1*04:01 positive.
Study context
- Population
- Patients diagnosed with both rheumatoid arthritis (RA) and granulomatosis with polyangiitis (GPA), followed at the authors' department for AAVall women
- Participants
- 6 patients
- Outcome
- Clinical features, ANCA status and HLA phenotypes
Methodological detailssingle-centre, Genomic HLA typing by routine methods
- Single-centre
- Genomic HLA typing by routine methods
Main finding
As reported in the abstract
- Women
- 6
- MPO-ANCA positive
- 5
- PR3-ANCA positive
- 1
- Erosive joint disease
- 5
- IgM-RF and/or anti-CCP positive
- 6
- Localized GPA
- 5
- Systemic GPA
- 1
- Subglottic stenosis
- 4
- Saddle nose deformity
- 3
- Median time between the two diagnoses, years (range 7-17)
- 13
- RA before GPA
- 4
- GPA before RA
- 2
Observational data: associations, not effects.
Original publication
Clinical features, anti-neutrophil cytoplasmic antibody (ANCA) status, and human leucocyte antigen (HLA) phenotypes of patients diagnosed with both rheumatoid arthritis and granulomatosis with polyangiitis: a case series of six patients with predominant myeloperoxidase (MPO)-ANCA positivity and HLA-DR4/DQ8/DPB1*04:01 phenotype. Scand J Rheumatol. Published 9 June 2026. doi:10.
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