Vasculitis & polymyalgia rheumatica
Myeloperoxidase–anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis
Authors' conclusion
Patients with MPO-ANCA-positive EGPA demonstrated different baseline clinical characteristics from MPO-ANCA-negative patients. However, subsequent relapses and serious infectious diseases were comparable.
Study context
- Population
- Patients with new-onset or severely relapsing eosinophilic granulomatosis with polyangiitis (EGPA) enrolled in the J-CANVAS registry; PR3-ANCA-positive patients excludednew onset 159
- Participants
- 166 patients
- Exposure
- MPO-ANCA-positive vs MPO-ANCA-negative EGPA
- MPO-ANCA positiven = 62
- MPO-ANCA negativen = 104reference
Methodological detailsregistry-based (J-CANVAS)
- Registry-based (J-CANVAS)
Main finding
As reported in the abstract
- MPO-ANCA positive had significantly more frequent mucous membrane and eye involvement, more frequent renal involvement, higher total BVAS, higher neutrophil counts and higher CRP at baseline
- No differences in age or sex between groups
- Incidence rates of severe relapse and minor relapse comparable; MPO-ANCA positivity not a significant factor in relapse (Cox regression)
Observational data: associations, not effects.
Further findings
Treatment
- RTX administered more frequently in MPO-ANCA positive; no other differences in treatment
eGFR and prednisolone doses · weeks 24 and 48
- Comparable in both groups
Safety
Serious infectious diseases
- Incidence rates comparable; MPO-ANCA positivity not a significant factor (Cox regression)
Original publication
Myeloperoxidase–anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis. Scand J Rheumatol. Published 4 November 2025. doi:10.
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