Vasculitis & polymyalgia rheumatica

Prevalence and Clinical Characteristics of Vasculitis in the Alaska Native and American Indian Peoples of Alaska

Arthritis Care Res (Hoboken)Published Cross-sectional study

Authors' conclusion

The prevalence of AAV (especially GPA) in AN/AI peoples is high. GCA prevalence is lower than White populations, but higher than many other populations.

Study context

Population
Adult Alaska Native and American Indian (AN/AI) peoples within the Alaska Tribal Health System (ATHS); denominator 2019 ATHS user population ≥ 18 (≥ 50 for GCA)
Outcome
Prevalence and clinical characteristics of vasculitis
Methodological detailselectronic health record query, medical record abstraction, age-adjusted prevalence
  • Electronic health record query
  • Medical record abstraction
  • Age-adjusted prevalence

Main finding

As reported in the abstract

Age-adjusted prevalence
All vasculitis, per 1,000,000 AN/AI adults
752 (95% CI 581-959)
Systemic vasculitis (most common), per 1,000,000 adults
518 (95% CI 379-695)
Antibody-associated vasculitis (AAV), per million adults
340 (95% CI 230-488)
GCA, per 100,000 ≥ 50
28 (95% CI 12-56)
Granulomatosis with polyangiitis (GPA) (most prevalent AAV subtype), per million adults
244 (95% CI 148-380)

Observational data: associations, not effects.

Further findings

Age at diagnosis

AAV, mean age in years (SD 17); often high markers of inflammation and renal involvement
54.2
GCA, mean age in years (SD 9.2)
69.6

Original publication

Prevalence and Clinical Characteristics of Vasculitis in the Alaska Native and American Indian Peoples of Alaska. Arthritis Care Res (Hoboken). Published 5 March 2025. doi:10.1002/acr.25506

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