Vasculitis & polymyalgia rheumatica
Giant cell arteritis-related cerebrovascular ischemic events: a French retrospective study of 271 patients, systematic review of the literature and meta-analysis
Authors' conclusion
The pooled prevalence of GCA-related CIE was 4%. Our cohort identified an association between GCA-related CIE, lower BMI, and vertebral, intracranial, and axillary arteries involvement on various imaging modalities.
Study context
- Population
- Consecutive patients with giant cell arteritis (GCA) (American College of Rheumatology (ACR) criteria), Lille University Hospital, January 1, 2010, to December 31, 2020; meta-analysis of cohort studies of unselected GCA patients reporting cerebrovascular ischemic events (CIE)89 males, mean age 72 ± 9 years
- Participants
- 271 patients
- Comparison
- GCA patients with vs without GCA-related CIE
- CIEn = 14
- Outcome
- Prevalence of GCA-related CIE
Methodological detailssingle-centre (Lille University Hospital), consecutive patients, MEDLINE and EMBASE search
- Single-centre (Lille University Hospital)
- Consecutive patients
- MEDLINE and EMBASE search
Pooled result
As reported in the abstract
Cohort prevalence of GCA-related CIE (14/271)
5.2%
Pooled prevalence of GCA-related CIE
4%
meta-analysis, 14 studies, 3553 patients; 95% CI 3–6, I2 = 68%
Further pooled results
Vertebral artery thrombosis on Doppler US
P = 0.012
Vertebral arteries involvement on CTA and/or MRA
P < 0.001
Intracranial arteries involvement on CTA and/or MRA
P < 0.001
Axillary arteries involvement on PET/CT
P = 0.016
CIE territory (cohort)
- Vertebrobasilar territory
- 8
- Carotid territory
- 5
- Multifocal ischemic and hemorrhagic strokes related to intra-cranial vasculitis
- 1
Body mass index (BMI)
- Lower BMI more frequent in GCA patients with CIE
Original publication
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