Vasculitis & polymyalgia rheumatica
Associations between circulating interleukin-17 levels and Behcet's disease and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis
Pooled result · Circulating IL-17 levelsResult — go to the resultSMD 1.422 95% CI 0.689–2.155Authors' conclusion
This meta-analysis revealed significantly higher circulating IL-17 levels in BD patients and showed evidence of associations between IL17A rs4711998 and rs8193036 polymorphisms and BD.
Study context
- Population
- Patients with Behçet's disease and controls; studies from Medline, Embase and Cochrane databases12 studies
- Participants
- 901 vs 1,131
- Comparison
- Behçet's disease (BD) patients vs controls
- BDn = 901
- Controlsn = 1,131reference
- Outcome
- Circulating (serum/plasma) IL-17 levels
Pooled result
Circulating IL-17 levels
SMD
1.422
95% CI 0.689–2.155
P < 0.001
BDvs Controls
SMD 1.422 (95% CI 0.689–2.155); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| IL17A rs4711998 polymorphism and BD | 1.347 (1.043–1.741) | P < 0.001 | |
| IL17A rs8193036 polymorphism and BD | 0.691 (0.542–0.880) | P = 0.003 | |
| 0.512Odds ratio (log scale) |
IL-17 levels by data type (subgroup)
- Higher IL-17 levels in BD in both original and calculated data populations
IL-17 levels, active vs inactive disease
- No significant differences in IL-17 levels between active and inactive disease
IL17A rs2275913, IL17F rs763780 and rs2397084 polymorphisms and BD
- No evidence of associations with BD
Original publication
Associations between circulating interleukin-17 levels and Behcet's disease and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis. Clin Exp Rheumatol. Published 17 May 2023. doi:10.
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