Systemic sclerosis & Raynaud's
Subclinical coronary artery calcification in systemic sclerosis using high-resolution chest CT: Identification, extent, and disease-specific risk factors
Authors' conclusion
Additionally, digital ulcers appear to be a novel risk factor for subclinical CAD in these patients.
Study context
- Population
- Patients with systemic sclerosis (SSc) with high-resolution computed tomography (HRCT) chest scans, compared with a background population from two cardiac CT screening cohorts
- Participants
- 394 SSc patients
- Exposure
- SSc patients vs background population
- SScn = 394
- Outcome
- Proportion with Agatston CAC score ≥100
Methodological detailslogistic regression adjusted for cardiovascular risk factors, HRCT coronary artery calcification (CAC) scores calibrated with a conversion factor
- Logistic regression adjusted for cardiovascular risk factors
- HRCT CAC scores calibrated with a conversion factor
Main finding
As reported in the abstract
CAC score ≥100
P < 0.001
Observational data: associations, not effects.
Further findings
CAC score of 0 (HRCT chest scans, SSc patients)
- CAC score of 0
- 116 (29.4 %)
Disease-specific risk factors independently associated with CAC score ≥100
- Disease duration, OR
- 1.05 (95% CI 1.01-1.09)
- History of digital ulcers, OR
- 2.25 (95% CI 1.31; 3.86)
Original publication
Subclinical coronary artery calcification in systemic sclerosis using high-resolution chest CT: Identification, extent, and disease-specific risk factors. Semin Arthritis Rheum. Published 10 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →