Systemic sclerosis & Raynaud's
Right atrial reservoir strain as an early predictor of pulmonary hypertension development in systemic sclerosis: a single-centre pilot study
Authors' conclusion
RARs may be a sensitive echocardiographic parameter to predict subsequent development of PH in patients with SSc.
Study context
- Population
- SSc patients followed at a Scleroderma Unit, May 2010 to April 2022, with complete echocardiographic examination including right atrial reservoir strain (RARs)10 developed pulmonary hypertension (PH)
- Participants
- 113 patients
- Outcome
- Development of PH predicted by RARs
- Follow-up
- Median 43 months
Methodological detailssingle-centre, pilot study, multivariable analysis, ROC analysis
- Single-centre
- Pilot study
- Multivariable analysis
- ROC analysis
Main finding
As reported in the abstract
RARs as predictor of PH development (multivariable analysis)
RARs, only echocardiographic parameter with significant independent predictive accuracy for PH: HR (95% CI 0.75-0.96), P = 0.01
0.85
PH confirmed by right heart catheterization (of 11 catheterized)
10
Observational data: associations, not effects.
Further findings
Optimal baseline RARs cut-off to predict PH (ROC)
- Cut-off
- 39.6
- AUC (P = 0.04)
- 0.7
- Sensitivity
- 70%
- Specificity
- 60%
Original publication
Right atrial reservoir strain as an early predictor of pulmonary hypertension development in systemic sclerosis: a single-centre pilot study. Rheumatology (Oxford). Published 9 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →