Lupus & antiphospholipid syndrome
Significance of the weighted complement domain of the EULAR/ACR classification criteria in juvenile onset systemic lupus erythematosus
Authors' conclusion
Observation of more frequent clinical and serological activity with higher total scores from the EULAR/ACR classification criteria supported the higher scoring of patients with low C3 and C4 in the weighted criteria.
Study context
- Population
- Patients with juvenile onset SLE fulfilling the 2019 EULAR/ACR classification criteria
- Participants
- 43 patients
- Exposure
- Low C3 and C4 vs other complement status at onset
- Outcome
- Hypocomplementemia
- Follow-up
- Disease onset
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Cutaneous involvementvs 28.6% | Low C3 and C4 65.2% | p: 0.045 |
| Musculoskeletal involvementvs 42.9% | Low C3 and C4 78.3% | p: 0.039 |
| Autoimmune hemolytic anemiavs 14.3% | Low C3 and C4 52.2% | p: 0.035 |
| Positive anti-dsDNAvs 21.4% | Low C3 and C4 65.2% | p: 0.017 |
| Anti-Sm antibodiesvs 21.4% | Low C3 and C4 60.9% | p: 0.04 |
| 2019 EULAR/ACR classification criteria scorevs 15.5 | Low C3 and C4 26 | p: < 0.0001 |
Remission, flare rates and SLE-associated damage (patients with hypocomplementemia)
- Did not differ according to complement status
Original publication
Significance of the weighted complement domain of the EULAR/ACR classification criteria in juvenile onset systemic lupus erythematosus. Lupus. Published 17 April 2023. doi:10.
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