Lupus & antiphospholipid syndrome
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
Authors' conclusion
Anti-KIF20B is a potential biomarker for SLE-related CN.
Study context
- Population
- Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria, enrolled from 31 centres 1999–2011 in the SLICC inception cohort, with baseline serum and 5 years of follow-upof 1827 enrolled
- Participants
- 795 individuals
- Exposure
- Anti-KIF20B-positive vs anti-KIF20B-negative, by cranial neuropathies (CN) status
- CNn = 10
- Without CNn = 785reference
- Outcome
- Association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN
- Follow-up
- First 5 years
Methodological detailsinternational inception cohort, multicentre (31 centres), logistic regression (penalised maximum likelihood, adjusted for confounders), Anti-KIF20B tested on baseline samples (within 15 months of diagnosis or first annual visit) by addressable laser bead immunoassay
- International inception cohort
- Multicentre (31 centres)
- Logistic regression (penalised maximum likelihood, adjusted for confounders)
- Anti-KIF20B tested on baseline samples (within 15 months of diagnosis or first annual visit) by addressable laser bead immunoassay
Main finding
As reported in the abstract
Anti-KIF20B positivity
CN vs Without CNOdds ratio (95% CI)
Anti-KIF20B positivity
5.2(1.4–18.5)
Multivariate, adjusted for age at baseline, female, White race and ethnicity, ACR haematological and ANA criteria
5.2(1.4–19.1)
Observational data: associations, not effects.
Further findings
| Outcome | CN | Without CN | Difference (95% CI) | |
|---|---|---|---|---|
| Fulfilment of ACR haematological criterion | 90.0% | 66.1% | 23.9% (5.0%–42.8%) | |
| Fulfilment of ACR ANA criterion | 100% | 95.7% | 4.3% (2.9%–5.8%) | |
| −200204060Difference (linear scale) |
Original publication
Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus. Lupus Sci Med. Published 9 April 2024. doi:10.
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