Lupus & antiphospholipid syndrome
Exacerbating effects of circadian rhythm disruption on the systemic lupus erythematosus
Authors' conclusion
Our study reveals that genetic characteristics arising from CRD can serve as biomarkers for predicting the exacerbation of SLE.
Study context
- Population
- Patients with SLE (clinical characteristics and transcriptional profiles)
- Participants
- 373 samples
- Outcome
- Impact of circadian rhythms on immune function and inflammation and their contribution to SLE progression to lupus nephritis (LN)
Main finding
As reported in the abstract
Circadian pathway enrichment in SLE (normalised enrichment score; lower enrichment suggested disease state)
0.6714
p=0.0062
Flare risk score (FRS) AUC, 5-year prediction of disease progression
0.76
Prognostic nomogram based on FRS, AUC
0.77
Observational data: associations, not effects.
Further findings
Mendelian randomisation: causal relationship of circadian rhythm disruption (CRD) with SLE and glomerular disorders
| OR (95% CI) | P value | ||
|---|---|---|---|
| CRDSLE; inverse causal relationship | 0.6284 (0.3630–1.0881) | P = 0.0485 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Mendelian randomisation: causal relationship of CRD with SLE and glomerular disordersCRD | 0.0337 (1.634e-3 to 6.934e-1) | P = 0.0280 |
- Mendelian randomisation: causal relationship of CRD with SLE and glomerular disorders: glomerular disorders; described as positive causal relationship
Original publication
Exacerbating effects of circadian rhythm disruption on the systemic lupus erythematosus. Lupus Sci Med. Published 9 April 2024. doi:10.
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