Systemic sclerosis & Raynaud's
Risk of kidney failure in patients with systemic sclerosis: a nationwide population-based study
Main finding · Kidney failureResult — go to the resultAdjusted hazard ratio 7.244 95% CI 4.256–12.329Authors' conclusion
The risk of kidney failure remains higher in patients with SSc than in the general population.
Study context
- Population
- Patients with systemic sclerosis (SSc) and matched controls, Korean National Health Insurance Service database, 2010–2017, followed to 2019follow-up 5.2±2.6 years
- Participants
- 2,591 vs 12,955
- Exposure
- SSc vs age- and sex-matched controls
- SScn = 2,591
- Controlsn = 12,955reference
- Outcome
- Kidney failure
Methodological detailsnationwide population-based, 1:5 age-matched and sex-matched controls, multivariable Cox proportional hazard models
- Nationwide population-based
- 1:5 age-matched and sex-matched controls
- Multivariable Cox proportional hazard models
Main finding
As reported in the abstract
Over 5.2±2.6 years
Adjusted hazard ratio
7.244
95% CI 4.256–12.329
By group
SScvs Controls
aHR 7.244 (95% CI 4.256–12.329)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Kidney failure by period of SSc diagnosis (subgroups)SSc diagnosed 2014–2017vs Controls | 9.754 (3.254–29.235) | |
| Kidney failure by period of SSc diagnosis (subgroups)SSc diagnosed before 2010vs Controls | 6.568 (2.711–15.571) | |
| Kidney failure by period of SSc diagnosis (subgroups)SSc diagnosed 2010–2013vs Controls | 6.553 (2.721–15.781) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Risk of kidney failure in patients with systemic sclerosis: a nationwide population-based study. RMD Open. Published 9 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →