Systemic sclerosis & Raynaud's
Heterogeneity of determining disease severity, clinical course and outcomes in systemic sclerosis-associated interstitial lung disease: a systematic literature review
Authors' conclusion
The studies presenting definitions of SSc-ILD 'progression', 'severity' and 'outcome' show a large heterogeneity.
Study context
- Population
- Studies of SSc-ILD recording definitions of severity, progression and outcomes342 papers included of 9054 reviewed
- Participants
- 342 participants
- Outcome
- Definitions of severity, progression and outcomes recorded for SSc-ILD
Methodological detailsPRISMA guidelines, Medline, Embase, Web of Science and Cochrane Library up to 1 August 2023
- PRISMA guidelines
- Medline, Embase, Web of Science and Cochrane Library up to 1 August 2023
Main finding
As reported in the abstract
- Most frequent tools: combined DLCO and forced vital capacity (FVC) changes, isolated FVC or DLCO changes, high-resolution CT (HRCT) extension, and composite algorithms (pulmonary function test, clinical signs and HRCT data)
- Mortality (all-cause or ILD related) was the most frequently reported long-term event
Original publication
Heterogeneity of determining disease severity, clinical course and outcomes in systemic sclerosis-associated interstitial lung disease: a systematic literature review. RMD Open. Published 8 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →