Systemic sclerosis & Raynaud's
Scoping literature review on applied definitions of very early diagnosis of systemic sclerosis (VEDOSS) and pre-systemic sclerosis in original articles
Authors' conclusion
This scoping review highlights the variability of the definitions of VEDOSS and pre-SSc that have been used in the literature. The absence of a consensus definition for pre-SSc contributes to overlapping and blurring boundaries between these concepts.
Study context
- Population
- Original articles applying definitions of VEDOSS or pre-SSc8 pre-SSc, 32 VEDOSS
- Participants
- 40 participants
- Outcome
- Existing definitions of pre-SSc and VEDOSS in the literature, item combinations used and conceptual variations
Methodological detailsPRISMA-ScR guidelines, PubMed and Web of Science searched
- PRISMA-ScR guidelines
- PubMed and Web of Science searched
Main finding
As reported in the abstract
- Records screened
- 106
- Articles originating from Europe
- 80%
- Distinct definitions of pre-SSc
- 3
- Different applications of VEDOSS criteria
- 13
- Studies citing the 2011 VEDOSS consensus
- 62.5%
- Studies applying the complete definition (three step 1 essential items and step 2 confirmation tools)
- 31.3%
Original publication
Scoping literature review on applied definitions of very early diagnosis of systemic sclerosis (VEDOSS) and pre-systemic sclerosis in original articles. RMD Open. Published 4 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →