Systemic sclerosis & Raynaud's
Factors associated with variations in the 6-minute walk distance during the follow-up of patients with systemic sclerosis
Authors' conclusion
While it remains valuable as a marker of disability and functioning, the variation in the 6MWD does not seem to be a robust surrogate for modifications in organ involvements of SSc patients.
Study context
- Population
- Consecutive patients with systemic sclerosis (SSc), including a subgroup with ILD or PH, followed over two years
- Participants
- 227 vs 88
- Exposure
- Global vs ILD or PH
- Globaln = 227
- ILD or PHn = 88
- Outcome
- Associations between variations in 6MWD (Δ6MWD) and evolution of organ involvement
- Follow-up
- two-year follow-up
Methodological detailsconsecutive patients, two-year follow-up, multivariate analysis
- Consecutive patients
- Two-year follow-up
- Multivariate analysis
Main finding
As reported in the abstract
Δ6MWD during follow-up
Global
- 11.6
mean · ± 67.5 · m
ILD or PH
- 16
mean · ± 74 · m
- Δ6MWD vs ΔΔBorg score
- P = 0.002
- Δ6MWD vs ΔNYHA
- P < 10- 3
- Δ6MWD vs Δright atrial area
- P = 0.045
- Δ6MWD vs persistently elevated Nt-pro-BNP levels
- P < 10- 3
- Δ6MWD vs ΔΔheart rate
- P = 0.015
- Δ6MWD vs Δinitial heart rate
- P = 0.024
- Δ6MWD vs occurrence of joint symptoms
- P = 0.006
- Δ6MWD vs ΔHAQ-DI score
- P = 0.023
- Multivariate model R2
- 0.53
- Multivariate model adjusted R2
- 0.36
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Factors associated with variations in the 6-minute walk distance during the follow-up of patients with systemic sclerosis. Arthritis Res Ther. Published 1 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →