Systemic sclerosis & Raynaud's
Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis
Authors' conclusion
Discordance between PtGA and PhGA occurs commonly, highlighting the need for comprehensive symptom management and measurement of disease burden in this complex disease.
Study context
- Population
- Adults with early systemic sclerosis (SSc) (<5 years) from the Collaborative National Quality and Efficacy Registry83% women, 33% limited disease
- Participants
- 956 adults
- Exposure
- Patient global assessment (PtGA) vs physician global assessment (PhGA)
- Outcome
- Factors associated with PtGA and PhGA and discordance (≥2 points) between them
Methodological detailsmultivariable mixed-effects linear regression, relative weight analysis, multinomial mixed-effects logistic regression, PtGA, PhGA, clinical evaluations and patient-reported outcomes (PROs) collected every six months
- Multivariable mixed-effects linear regression
- Relative weight analysis
- Multinomial mixed-effects logistic regression
- PtGA, PhGA, clinical evaluations and PROs collected every six months
Main finding
As reported in the abstract
enrollment
PtGA
4.2
mean · SD 2.6
PhGA
3.4
mean · SD 2.0
P < 0.001
- Discordance (≥2 points)
- 53%
- PtGA worse
- 35%
- PhGA worse
- 18%
Observational data: associations, not effects.
Original publication
Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis. Arthritis Care Res (Hoboken). Published 20 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →