Systemic sclerosis & Raynaud's
Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort
Authors' conclusion
Male patients with SSc have more extractable nuclear antigen antibody positivity and reduced survival in comparison to female patients.
Study context
- Population
- Patients with Systemic Sclerosis (SSc) in the Australian Scleroderma Cohort Studyfemale-to-male ratio 5.8:1
- Participants
- 2,033 patients
- Exposure
- Male vs female patients with SSc
- Malen = 299
- Outcome
- Differences in demographic, serologic and clinical characteristics between male and female patients
Methodological detailsmulticentre, longitudinal cohort (Australian Scleroderma Cohort Study), multivariate Cox proportional hazards model, subanalysis of incident SSc
- Multicentre
- Longitudinal cohort (Australian Scleroderma Cohort Study)
- Multivariate Cox proportional hazards model
- Subanalysis of incident SSc
Main finding
As reported in the abstract
Diffuse skin involvement
P < 0.001
Observational data: associations, not effects.
Further findings
10-year survival from diagnosis, incident SSc (subanalysis)
P < 0.001
- 10-year survival from diagnosis, incident SSc (subanalysis): incident SSc: disease duration <4 years from first non-Raynaud manifestation to recruitment
10-year survival from diagnosis, incident SSc (subanalysis)
- Males had significantly higher mortality
Original publication
Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort. Arthritis Care Res (Hoboken). Published 3 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →