Systemic sclerosis & Raynaud's
Non-surgical local treatments of digital ulcers in systemic sclerosis: a systematic literature review
Authors' conclusion
A range of non-surgical, local treatments for SSc-DUs have been explored and showed efficacy to some extent.
Study context
- Population
- Patients with systemic sclerosis (SSc) and digital ulcers; original research articles up to August 29, 202214 articles (2 randomised trials (RTs), 12 observational (OBS))
- Comparison
- Botulin A toxin vs Amniotic and hydrocolloid membranes vs Tadalafil 2% cream vs Vitamin E gel vs Low-level light therapy vs hydrodissection and corticosteroid injection vs extracorporeal shock wave (ESW) vs photobiomodulation vs Dimethyl sulfoxide
- Outcome
- Safety and efficacy of local, non-surgical treatment for SSc-DUs
Methodological detailsPICO framework, narrative summaries, 899 references retrieved, References independently screened by two reviewers; risk of bias assessed using validated tools
- PICO framework
- Narrative summaries
- 899 references retrieved
- References independently screened by two reviewers; risk of bias assessed using validated tools
Main finding
As reported in the abstract
Efficacy of local non-surgical treatments for SSc-DUs
Botulin A toxin
71%-100%
healing rate
Safety
- Dimethyl sulfoxide associated with significant local toxicity
Original publication
Non-surgical local treatments of digital ulcers in systemic sclerosis: a systematic literature review. Semin Arthritis Rheum. Published 26 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →