Systemic sclerosis & Raynaud's
MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study
Authors' conclusion
DAVIX is a promising surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis.
Study context
- Population
- Patients aged ≥18 years with SSc (very early diagnosis of systemic sclerosis (VEDOSS) or 2013 ACR-EULAR criteria) in the STRIKE study, Scleroderma Clinic, Leeds Teaching Hospitals Trust, Leeds, UK85 exploratory, 150 validation cohort
- Exposure
- MRI DAVIX in patients with vs without digital ulcer disease
- Outcome
- Presence of digital ulcers
- Follow-up
- 12-month follow-up
Methodological detailsobservational, exploratory and validation cohorts, consecutive enrolment, single-centre, Enrolment Feb 7, 2018 to April 11, 2022, DAVIX: percentage mean ratio of digital artery volume to finger volume in four fingers of dominant hand
- Observational
- Exploratory and validation cohorts
- Consecutive enrolment
- Single-centre
- Enrolment Feb 7, 2018 to April 11, 2022
- DAVIX: percentage mean ratio of digital artery volume to finger volume in four fingers of dominant hand
Main finding
As reported in the abstract
DAVIX in patients developing new digital ulcers
P = 0.0039
Observational data: associations, not effects.
Further findings
| Outcome | Previous or active DU | No DU | P value |
|---|---|---|---|
| DAVIX by previous or active DU, exploratory cohort · baseline | 0.34% (IQR 0.16–0.69) | 0.65% (IQR 0.42–0.88) | P = 0.015 |
| DAVIX by previous or active DU, validation cohort · baseline | 0.43% (IQR 0.20–0.73) | 0.73% (IQR 0.53–0.97) | P < 0.0001 |
Correlations of DAVIX with clinical features
- Disease duration, r (p<0.0001)
- −0.415
- FVC/DLCO ratio, r (p=0.0091)
- −0.334
- Nailfold capillaroscopy pattern, r (p<0.0001)
- −0.447
- Baseline mRSS, r (p=0.014)
- −0.305
- DLCO, r (p=0.0041)
- 0.368
Correlations of DAVIX with change in patient-reported outcomes
- Change in Scleroderma HAQ-DI, r (p=0.024)
- −0.308
- Change in Visual Analogue Scale (VAS) Raynaud's, r (p=0.044)
- −0.271
- Change in VAS digital ulcers, r (p=0.044)
- −0.291
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study. Lancet Rheumatol. Published 25 September 2023. doi:10.
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