Systemic sclerosis & Raynaud's
Scleroderma calcinosis cutis score (SC2S): an imaging metric to quantify SSc-calcinosis cutis
Authors' conclusion
SC2S may be a highly reproducible, broadly applicable, quantitative outcome that is sensitive to CC change. SC2S highlights the variable response of SSc-CC to STS treatment.
Study context
- Population
- Women with SSc-calcinosis cutis (CC) involving the arm, ischial tuberosities, hands and patellae, with a painful lesionall women
- Participants
- 5 women
- Comparison
- CC volume on CT before vs after 6-12 months of 25% sodium thiosulphate (STS)
- Topical STSn = 2
- Intradermal STSn = 3
- Outcome
- CC volume quantified by computer-assisted CT mapping (scleroderma calcinosis cutis score, SC2S)
- Follow-up
- After 6-12 months of STS
Methodological detailscomputer-assisted CT lesion mapping, three independent assessors, open-source software (BioImageSuite/BIS Web)
- Computer-assisted CT lesion mapping
- Three independent assessors
- Open-source software (BioImageSuite/BIS Web)
Main finding
As reported in the abstract
- Inter-rater agreement between independent assessors, intraclass correlation coefficient
- 0.93
- SC2S change, left buttock
- 75% reduction
- SC2S change, right buttock
- 10% reduction
- SC2S change, arm
- 28% reduction
- SC2S change, left forefinger
- 18% increase
- SC2S change, right hand
- 27% increase
- SC2S change, left patella
- 12% reduction
- SC2S change, right patella
- 4% increase
Further findings
CC volume differences on repeated measures 1 week apart
- Difference on repeated measures
- ≤3%
Mapping time
- Arm and buttock
- <30 min
- Finger/hand and patellae
- >4 h
Original publication
Scleroderma calcinosis cutis score (SC2S): an imaging metric to quantify SSc-calcinosis cutis. Rheumatology (Oxford). Published 11 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →