Systemic sclerosis & Raynaud's
Progressive pulmonary fibrosis and its impact on survival in systemic sclerosis-related interstitial lung disease
Authors' conclusion
PPF occurred in a third of our incident SSc-ILD cohort; however, its occurrence was significantly associated with mortality
Study context
- Population
- Incident SSc-ILD cases (new characteristic fibrotic changes on chest HRCT)
- Outcome
- Frequency of PPF (2022 American Thoracic Society definition)
- Follow-up
- Within a 12-month period after ILD diagnosis
Methodological detailsincident cohort, generalised estimating equations, accelerated failure time regression modelling
- Incident cohort
- Generalised estimating equations
- Accelerated failure time regression modelling
Main finding
As reported in the abstract
PPF · within 12 months after ILD diagnosis
Incident SSc-ILD
38.8%
180 events
Observational data: associations, not effects.
Further findings
Determinants of progressive pulmonary fibrosis (PPF) · 12 months after interstitial lung disease (ILD) diagnosis
| OR (95% CI) | P value | ||
|---|---|---|---|
| Older ageGeneralised estimating equations | 1.02 (1.00–1.03) | P = 0.011 | |
| dcSScGeneralised estimating equations | 1.54 (1.06–2.25) | P = 0.024 | |
| Anticentomere antibodyGeneralised estimating equations | 0.51 (0.29–0.91) | P = 0.021 | |
| anti-Scl-70 antibodyGeneralised estimating equations | 1.46 (1.01–2.09) | P = 0.043 | |
| Raised CRPGeneralised estimating equations | 1.29 (0.99–1.68) | P = 0.064 | |
| GORDGeneralised estimating equations | 1.18 (0.57–2.42) | P = 0.658 | |
| DysphagiaGeneralised estimating equations | 1.17 (0.57–2.40) | P = 0.664 | |
| 0.20.5125Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Progressive pulmonary fibrosis and its impact on survival in systemic sclerosis-related interstitial lung disease. Rheumatology (Oxford). Published 19 September 2023. doi:10.
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