Systemic sclerosis & Raynaud's
The prognostic importance of worsening dyspnoea in systemic sclerosis related interstitial lung disease
Authors' conclusion
Patient-reported worsening dyspnoea in the month prior, irrespective of changes in spirometry, was strongly associated with mortality, with a magnitude equivalent to that of the presence of progressive ILD as defined by the ATS, INBUILD and spirometric definitions of progressive ILD.
Study context
- Population
- Systemic sclerosis (SSc) patients from the Australian Scleroderma Cohort Study; Interstitial lung disease (ILD) defined by characteristic fibrotic changes on high-resolution computer tomography (HRCT)389 incident ILD
- Participants
- 2,198 patients
- Exposure
- Worsening dyspnoea in the prior month vs none, among SSc-ILD with progressive ILD
- Outcome
- Mortality (determinants of survival in SSc-ILD)
Methodological detailsaccelerated failure time survival analysis
- Accelerated failure time survival analysis
Main finding
As reported in the abstract
Mortality in progressive ILD by recent worsening dyspnoea
- Mortality significantly higher with recent worsening dyspnoea in the prior month, irrespective of a decline in spirometric parameters
Observational data: associations, not effects.
Further findings
Incident ILD · median (IQR) follow-up 5.8 (2.8-9.9) years
- Developed incident ILD (n = 389)
- 17.7%
Progressive ILD among incident ILD
- Experienced progressive ILD (n = 149)
- 38.3%
- Conclusion prints 38.8%
Original publication
The prognostic importance of worsening dyspnoea in systemic sclerosis related interstitial lung disease. Semin Arthritis Rheum. Published 5 September 2025. doi:10.
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