Systemic sclerosis & Raynaud's
The chest CT signs for pulmonary veno-occlusive disease correlate with pulmonary haemodynamics in systemic sclerosis
Authors' conclusion
The CT signs for PVOD had a positive correlation with mPAP but a negative correlation with DLCO in SSc patients, indicating that PAH-SSc may reflect a spectrum of pulmonary vascular disease that ranges from the pulmonary artery to the vein.
Study context
- Population
- Consecutive SSc patients with pulmonary haemodynamic abnormalities (mean pulmonary arterial pressure (mPAP) >20 mmHg, pulmonary vascular resistance >2 WU or pulmonary artery wedge pressure (PAWP) >15 mmHg)
- Participants
- 52 patients
- Exposure
- 2-3 chest CT signs for pulmonary veno-occlusive disease (PVOD) vs 0-1 signs
- 2-3n = 15
- 0-1n = 37reference
- Outcome
- Pulmonary haemodynamics and pulmonary function by number of CT signs for PVOD
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- PAWP, cardiac output, LV ejection fraction, left atrial diameter, FVC, brain natriuretic peptide and Krebs von den Lunge-6 not different between the two groups
- 2-3 vs 0-1: P = 0.02
- 2-3 vs 0-1: P = 0.02
Observational data: associations, not effects.
Further findings
Frequency of chest CT signs for PVOD (all patients)
- Mediastinal lymph node enlargement
- 11 (21%)
- Thickened interlobular septal wall
- 32 (62%)
- Ground glass opacity
- 11 (21%)
Original publication
The chest CT signs for pulmonary veno-occlusive disease correlate with pulmonary haemodynamics in systemic sclerosis. Rheumatology (Oxford). Published 15 September 2023. doi:10.
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