Systemic sclerosis & Raynaud's
Quantitative HRCT as a surrogate outcome measure for nintedanib treatment in systemic sclerosis-interstitial lung disease and idiopathic pulmonary fibrosis
Authors' conclusion
NIN appears effective in reducing the radiological decline of pulmonary fibrosis.
Study context
- Population
- Patients with SSc-associated progressive ILD and idiopathic pulmonary fibrosis
- Participants
- 36 vs 36
- Exposure
- Nintedanib vs untreated historical cohort
- NINn = 36
- Untreatedn = 36reference
- Outcome
- Quantitative HRCT changes: percentage of normal parenchyma, ILD and vascular-related structures (CALIPER)
- Follow-up
- Mean 22 months
Methodological detailsprospective enrolment of treated patients, retrospectively selected historical untreated cohort comparable for disease, age, gender and follow-up period, quantitative HRCT (CALIPER software)
- Prospective enrolment of treated patients
- Retrospectively selected historical untreated cohort comparable for disease, age, gender and follow-up period
- Quantitative HRCT (CALIPER software)
Main finding
As reported in the abstract
Quantitative HRCT change from baseline (% normal parenchyma and % ILD)
- NIN: normal parenchyma from 81.3±11.8% to 78.6±15.6%
- P=not significant
- NIN: ILD from 14.5±10.4% to 16.7±14.2%
- P=not significant
- Untreated: normal parenchyma from 87.4±7.3% to 78.8±16.7%
- P<0.001
- Untreated: ILD from 9.0±5.9% to 16.5±14.8%
- P<0.001
Observational data: associations, not effects.
Further findings
Vascular-related structures (VRS) · mean follow-up 22 months
- VRS significantly increased regardless of antifibrotic therapy
- P < 0.001
NIN-treated patients with clinically meaningful worsening of pulmonary function tests or reported dyspnoea (subgroup)
- Significant loss of normal parenchyma in parallel with a greater increase in ILD
- P < 0.05 for all
Original publication
Quantitative HRCT as a surrogate outcome measure for nintedanib treatment in systemic sclerosis-interstitial lung disease and idiopathic pulmonary fibrosis. Joint Bone Spine. Published 24 June 2025. doi:10.
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