Systemic sclerosis & Raynaud's
Distribution of white matter hyperintensity in Systemic Sclerosis (SSc) patients: a monocenter, cross-sectional magnetic resonance imaging study
Authors' conclusion
These findings suggested that SSc patients are more likely to acquire WMH, particularly in the deep white matter regions.
Study context
- Population
- SSc patients and healthy controls undergoing brain magnetic resonance (MR)
- Exposure
- SSc patients vs healthy controls; dcSSc vs lcSSc
- SScn = 84
- Healthy controls (HCs)n = 30reference
- Outcome
- Quantitative characteristics and distribution patterns of WMH (periventricular hyperintensity (PVH) and DWMH) on MR imaging
Methodological detailsmonocenter, MRI study
- Monocenter
- MRI study
Main finding
As reported in the abstract
Proportion of DWMH (WMH more prevalent in SSc)
SSc
2.28 × 10-4
IQR 0.35 × 10-4, 9.68 × 10-4
P = 0.0339
Observational data: associations, not effects.
Further findings
| Outcome | dcSSc | lcSSc | P value |
|---|---|---|---|
| PVH/WMH proportion corrected residual value, by SSc subtypedcSSc vs lcSSc | 0.06 (IQR −0.15–0.17) | −0.16 (IQR −0.30–0.13) | P = 0.0346 |
Scale results (cognition, anxiety/depression) vs White matter hyperintensities (WMH) volume ratios
- No correlations were found between scales results and WMH volume ratios
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Distribution of white matter hyperintensity in SSc patients: a monocenter, cross-sectional magnetic resonance imaging study. Rheumatology (Oxford). Published 23 June 2025. doi:10.
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