Systemic sclerosis & Raynaud's
Validation of Lung Ultrasound Interpretation Criteria for Interstitial Lung Disease in Systemic Sclerosis and Inflammatory Myopathy
Authors' conclusion
We validated our revised LUS-ILD-24 in cohorts with SSc and IM and found excellent sensitivity, specificity, and reliability for detection of ILD identified on CT imaging. LUS severity correlated with CT and pulmonary function test markers of ILD severity.
Study context
- Population
- Patients meeting criteria for systemic sclerosis (SSc) and inflammatory myopathy (IM) with planned computed tomography (CT) chest imagingincluded in analyses
- Participants
- 95 patients
- Comparison
- Lung ultrasound (LUS) interpreted with LUS-ILD-24 vs CT chest imaging for interstitial lung disease (ILD) detection
- Outcome
- Sensitivity and specificity of LUS-ILD-24 for ILD detection as noted on CT
Methodological detailsvalidation study, three blinded readers, CT as reference
- Validation study
- Three blinded readers
- CT as reference
Performance
As reported in the abstract
Detection of ILD on CT by LUS-ILD-24 (3 blinded readers)
Sensitivity for ILD detection, range across readers
92.4% to 95.5%
Specificity for ILD detection, range across readers
82.8% to 86.2%
Further findings
Inter- and intrareader reliability
- Interreader κ (near perfect agreement)
- 0.92
- Intrareader κ (near perfect agreement)
- 0.90 to 1
Correlation of LUS severity with CT severity and pulmonary function
- LUS severity correlated with CT imaging severity and inversely with DLCO and FVC
Original publication
Validation of Lung Ultrasound Interpretation Criteria for Interstitial Lung Disease in Systemic Sclerosis and Inflammatory Myopathy. Arthritis Care Res (Hoboken). Published 22 June 2025. doi:10.
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