Systemic sclerosis & Raynaud's
Reproductive health in female patients with systemic sclerosis: a cross-sectional study
Authors' conclusion
The impairment of reproductive health is common and in many quarters in patients with SSc.
Study context
- Population
- Female patients with systemic sclerosis (SSc) from the Chinese Organization for Scleroderma
- Participants
- 342 patients
- Exposure
- Female patients with SSc vs national data and matched healthy controls
- SScn = 342
- Outcome
- Status of reproductive health (fertility condition and menstrual status)
Methodological detailsquestionnaire-based, pregnancies matched with healthy controls
- Questionnaire-based
- Pregnancies matched with healthy controls
Main finding
As reported in the abstract
Problems with reproductive health
SSc
31.8%
108
Observational data: associations, not effects.
Further findings
| Outcome | SSc | Healthy control | National data | P value |
|---|---|---|---|---|
| Menopausal age, patients with disease onset before menopauseSSc vs National data · earlier menopause in SSc | 45.2 ± 6.1 | — not stated in the abstract | 48.2 ± 4.4 | P < 0.001 |
| Spontaneous abortionsSSc vs National data · 9/74 in SSc | 12.2% | — not stated in the abstract | 4.3% | P < 0.001 |
| Premature infantsSSc vs Healthy control | 21.8% | 6.4% | — not stated in the abstract | P = 0.003 |
| Low birth weight infantsSSc vs Healthy control | 27.3% | 5.5% | — not stated in the abstract | P < 0.001 |
| Cesarean sectionSSc vs Healthy control | 49.1% | 19.1% | — not stated in the abstract | P < 0.001 |
— not stated in the abstract
- Premature infants: 12/55 vs 7/110
- Low birth weight infants: 15/55 vs 6/110
- Cesarean section: 27/55 vs 21/110
Factors associated with menopausal age
- Age of disease onset
- P = 0.018
- Digital ulcer
- P = 0.020
Infertility rate
- Not increased vs national data
Original publication
Reproductive health in female patients with systemic sclerosis: a cross-sectional study. Rheumatology (Oxford). Published 20 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →