Systemic sclerosis & Raynaud's
Heart and systemic sclerosis—findings from a national cohort study
Authors' conclusion
Our results describe the incidence and prognostic burden of SSc-related cardiac involvement at a large scale, with gender and diffuse SSc subtype as risk factors.
Study context
- Population
- Patients with SSc in the French SSc national database1,646 available for follow-up
- Participants
- 3,528 patients
- Outcome
- Incidence and risk factors of SSc-related cardiac involvement
Methodological detailsmulticentre, national database
- Multicentre
- National database
Main finding
As reported in the abstract
SSc-related cardiac involvement
Prevalence at baseline
312
10.9%
Developed at 5 years
98
5-year event rate
11.15%
Observational data: associations, not effects.
Further findings
Reduced LV ejection fraction <50% · 5 years
- 5-year event rate
- 2.49%
LV diastolic dysfunction · 5 years
- 5-year event rate
- 5.84%
- Female sex associated with less incidence
Pericarditis · 5 years
- Cumulative incidence
- 3%
- Diffuse SSc subtype a risk factor
Original publication
Heart and systemic sclerosis—findings from a national cohort study. Rheumatology (Oxford). Published 7 November 2023. doi:10.
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